Title

An Efficient, Regiocontrolled Synthesis Of 5-Aryl-2-Carbethoxypyrroles From 3-Aryl-3-Chloropropeniminium Salts

Authors

J T. Gupton

Title - Alternative

Synth. Commun.

Keywords

PYRROLE-2-CARBOXYLATES; 1, 3-DIKETONES; HETEROCYCLES; Chemistry, Organic

Abstract

A variety of 3-aryl-3-chloropropeniminium salts react with alpha-amino acid esters under basic conditions to produce 2-carbethoxy-5-arylpyrroles in a regioselective manner. The overall process represents a short, efficient, and convergent synthesis of 2,5-disubstituted pyrroles, and azomethine ylides or azapentadienyl anions may be involved as intermediates.

Publication Title

Synthetic Communications

Volume

22

Issue/Number

20

Publication Date

1-1-1992

Document Type

Article

Language

English

First Page

5480

Last Page

5483

WOS Identifier

WOS:A1992KD68600006

ISSN

0022-3263

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