Title

Crystal And Molecular-Structure Of An Active Carbinolamide - 4-Hydro-4-Dimethoxymethyl-6-Isopropyl-2-Oxo-2,3-Dihydro(6H)-1,3-Oxazine

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Abbreviated Journal Title

J. Heterocycl. Chem.

Keywords

Chemistry; Organic

Abstract

The crystal and molecular structure of the title compound has been determined by single-crystal x-ray diffraction techniques. The compound is of interest because of its own intrinsic anti-tumor activity and because it is also a common moiety of a series of more active anti-tumor agents, the maytansinoids. The compound crystallizes in the space group PĪ with 2 molecules in a unit-cell of dimensions a = 6.912 Å,b = 7.219 Å,c = 15.272 Å, α = 119.96°, β = 104.30° and γ = 96.04°. The structure was solved by direct methods and refined to a final value of R = 0.063.

Journal Title

Journal of Heterocyclic Chemistry

Volume

18

Issue/Number

8

Publication Date

1-1-1980

Document Type

Article

Language

English

First Page

1541

WOS Identifier

WOS:A1981NB70200010

ISSN

0022-152X

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