Title

Reactions Of Beta-Fluorovinamidinium Salt With Bifunctional Hetero Nucleophiles - A New Synthetic Route To Fluorinated Heterocycles

Authors

Authors

X. F. Shi; T. Ishihara; H. Yamanaka;J. T. Gupton

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Tetrahedron Lett.

Keywords

VINAMIDINIUM SALTS; (POLYFLUORO-1-PROPENYL)TRIMETHYLAMMONIUM; Chemistry, Organic

Abstract

beta-Fluorovinamidinium salt (2), readily prepared from N-(2,3,3-trifluoro-1-propenyl)trimethylammonium iodide (1) and diethylamine, reacted with bifunctional hetero nucleophiles such as amidine and guanidine hydrochlorides in the presence of a base to afford regiospecifically monofluorinated pyrimidines 4 in good yields. The one-pot procedure starting from 1 was applicable for synthesizing heterocyclic compounds 4 in almost comparable yields.

Journal Title

Tetrahedron Letters

Volume

36

Issue/Number

9

Publication Date

1-1-1995

Document Type

Article

Language

English

First Page

1527

Last Page

1530

WOS Identifier

WOS:A1995QK51800040

ISSN

0040-4039

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