Reactions Of Beta-Fluorovinamidinium Salt With Bifunctional Hetero Nucleophiles - A New Synthetic Route To Fluorinated Heterocycles
Abbreviated Journal Title
VINAMIDINIUM SALTS; (POLYFLUORO-1-PROPENYL)TRIMETHYLAMMONIUM; Chemistry, Organic
beta-Fluorovinamidinium salt (2), readily prepared from N-(2,3,3-trifluoro-1-propenyl)trimethylammonium iodide (1) and diethylamine, reacted with bifunctional hetero nucleophiles such as amidine and guanidine hydrochlorides in the presence of a base to afford regiospecifically monofluorinated pyrimidines 4 in good yields. The one-pot procedure starting from 1 was applicable for synthesizing heterocyclic compounds 4 in almost comparable yields.
"Reactions Of Beta-Fluorovinamidinium Salt With Bifunctional Hetero Nucleophiles - A New Synthetic Route To Fluorinated Heterocycles" (1995). Faculty Bibliography 1990s. 1462.