Title

IMPAIRED BAROREFLEX CONTROL OF RENAL SYMPATHETIC NERVE ACTIVITY IN TYPE 1 DIABETIC MICE (OVE26)

Authors

Authors

H. Gu; Z. H. Zhang; P. N. Epstein; L. Li; S. W. Harden; R. D. Wurster;Z. J. Cheng

Comments

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Abbreviated Journal Title

Neuroscience

Keywords

baroreflex; baroreceptor; sympathetic; neuropathy; nephropathy; diabetes; mellitus; CARDIAC REFLEX SENSITIVITY; BARORECEPTOR REFLEX; SUDDEN-DEATH; ORTHOSTATIC HYPOTENSION; AUTONOMIC NEUROPATHY; EFFERENT COMPONENTS; DIETARY MYOINOSITOL; BED SYNDROME; STREPTOZOTOCIN; MELLITUS; Neurosciences

Abstract

To investigate the effects of chronic diabetes on baroreflex control of renal sympathetic nerve activity (RSNA), OVE26 diabetic (transgenic mouse line which develops hyperglycemia within the first 3 weeks after birth) and FVB control mice 5-6 months old were studied. Under anesthesia, RSNA in response to sodium nitroprusside (SNP)- and phenylephrine (PE)-induced mean arterial pressure changes (Delta MAP) were measured. Baroreflex-induced inhibition of RSNA during PE infusion was characterized using the sigmoid logistic function curve. Baroreflex-induced excitation of RSNA during SNP infusion was characterized by the RSNA vs. Delta MAP relationship. Mean arterial pressure (MAP) responses to the left aortic depressor nerve (ADN) stimulation were evaluated. Compared to FVB control, we found in OVE26 mice that (1) RSNA in response to MAP increase during PE infusion was dramatically reduced, as characterized by the maximal gain of the RSNA sigmoid logistic function curve (FVB: -20.0 +/- 5.1; OVE26: -7.6 +/- 0.8%/mm Hg, P<0.05); (2) RSNA in response to MAP decrease during SNP infusion was also attenuated (P<0.05); (3) MAP responses to ADN stimulation were reduced (P<0.05). We concluded that chronic diabetes impairs baroreflex control of RSNA in OVE26 diabetic mice. The use of the transgenic OVE26 diabetic mouse model may underlie a foundation for the further understanding of diabetes-induced autonomic neuropathy. Published by Elsevier Ltd on behalf of IBRO.

Journal Title

Neuroscience

Volume

161

Issue/Number

1

Publication Date

1-1-2009

Document Type

Article

Language

English

First Page

78

Last Page

85

WOS Identifier

WOS:000266225900011

ISSN

0306-4522

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