Multiplexed highly sensitive detections of cancer biomarkers in thermal space using encapsulated phase change nanoparticles
Abbreviated Journal Title
Appl. Phys. Lett.
biothermics; cancer; molecular biophysics; nanobiotechnology; nanoparticles; patient diagnosis; phase change materials; silicon; compounds; tumours; GOLD NANOPARTICLES; ENERGY STORAGE; DNA; NANOCRYSTALS; PROTEINS; PROBES; Physics, Applied
We describe a multiplexed highly sensitive method to detect cancer biomarkers using silica encapsulated phase change nanoparticles as thermal barcodes. During phase changes, nanoparticles absorb heat energy without much temperature rise and show sharp melting peaks (0.6 degrees C). A series of phase change nanoparticles of metals or alloys can be synthesized in such a way that they melt between 100 and 700 degrees C, thus the multiplicity could reach 1000. The method has high sensitivity (8 nM) that can be enhanced using materials with large latent heat, nanoparticles with large diameter, or reducing the grafting density of biomolecules on nanoparticles.
Applied Physics Letters
"Multiplexed highly sensitive detections of cancer biomarkers in thermal space using encapsulated phase change nanoparticles" (2009). Faculty Bibliography 2000s. 1847.