CNTF 1357 G -> A polymorphism and the muscle strength response to resistance training
Abbreviated Journal Title
J. Appl. Physiol.
ciliary neurotrophic factor; exercise; genomics; muscle mass; CILIARY NEUROTROPHIC FACTOR; FAT-FREE MASS; ADULT AGE SPAN; MUSCULAR; STRENGTH; ACTN3 GENOTYPE; RECEPTOR GENE; OLDER-ADULTS; WOMEN; MEN; PHENOTYPES; Physiology; Sport Sciences
Walsh S, Kelsey BK, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Seip RL, Bilbie S, Thompson PD, Hoffman EP, Price TB, Devaney JM, Pescatello LS. CNTF 1357 G -> A polymorphism and the muscle strength response to resistance training. J Appl Physiol 107: 1235-1240, 2009. First published July 23, 2009; doi:10.1152/japplphysiol.90835.2008.-The present study examined associations between the ciliary neurotrophic factor (CNTF) 1357 G 3 A polymorphism and the muscle strength response to a unilateral, upper arm resistance-training (RT) program among healthy, young adults. Subjects were 754 Caucasian men (40%) and women (60%) who were genotyped and performed a training program of the nondominant (trained) arm with the dominant (untrained) arm as a comparison. Peak elbow flexor strength was measured with one repetition maximum, isometric strength with maximum voluntary contraction, and bicep cross-sectional area with MRI in the trained and untrained arms before and after training. Women with the CNTF GG genotype gained more absolute isometric strength, as measured by MVC (6.5 +/- 0.3 vs. 5.2 +/- 0.5 kg), than carriers of the CNTF A1357 allele in the trained arm pre- to posttraining (P < 0.05). No significant associations were seen in men. Women with the CNTF GG genotype gained more absolute dynamic (1.0 +/- 0.1 vs. 0.6 +/- 0.1 kg) and allometric (0.022 +/- 0.0 vs. 0.015 +/- 0.0 kg/kg(-0.67)) strength, as measured by 1 RM, than carriers of the CNTF A1357 allele in the untrained arm pre- to posttraining (P < 0.05). No significant associations were seen in men. No significant associations, as measured by cross-sectional area, were seen in men or women. The CNTF 1357 G -> A polymorphism explains only a small portion of the variability in the muscle strength response to training in women.
Journal of Applied Physiology
"CNTF 1357 G -> A polymorphism and the muscle strength response to resistance training" (2009). Faculty Bibliography 2000s. 2274.