Title

Polymer translocation through a nanopore induced by adsorption: Monte Carlo simulation of a coarse-grained model

Authors

Authors

A. Milchev; K. Binder;A. Bhattacharya

Abbreviated Journal Title

J. Chem. Phys.

Keywords

BEAD-SPRING MODEL; POLYNUCLEOTIDE MOLECULES; DYNAMIC PROPERTIES; SCALING; THEORY; CHAINS; TRANSPORT; MEMBRANE; PORES; SURFACE; HOLE; Physics, Atomic, Molecular & Chemical

Abstract

Dynamic Monte Carlo simulation of a bead-spring model of flexible macromolecules threading through a very narrow pore in a very thin rigid membrane are presented, assuming at the cis side of the membrane a purely repulsive monomer-wall interaction, while the trans side is attractive. Two choices of monomer-wall attraction epsilon are considered, one choice is slightly below and the other slightly above the "mushroom to pancake" adsorption threshold epsilon(c) for an infinitely long chain. Studying chain lengths N=32, 64, 128, and 256 and varying the number of monomers N-trans (time t=0) that have already passed the pore when the simulation started, over a wide range, we find for epsilonepsilon(c) a finite number N-trans(t=0) suffices that the translocation probability is close to unity. In the case epsilonepsilon(c), we find that the translocation time scales as tauproportional toN(1.65+/-0.08). We suggest a tentative scaling explanation for this result. Also the distribution of translocation times is obtained and discussed. (C) 2004 American Institute of Physics.

Journal Title

Journal of Chemical Physics

Volume

121

Issue/Number

12

Publication Date

1-1-2004

Document Type

Article

Language

English

First Page

6042

Last Page

6051

WOS Identifier

WOS:000223872000056

ISSN

0021-9606

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