Title

Combining one-sided and two-sided confidence interval procedures for successive comparisons of ordered treatment effects

Authors

Authors

P. Somerville; T. Miwa; W. Liu;A. Hayter

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Biom. J.

Keywords

critical points; directional decisions; multivariate-t distribution; ordered inference; pairwise comparisons; simultaneous confidence; intervals; Mathematical & Computational Biology; Statistics & Probability

Abstract

LEE and SPURRIER (1995) present one-sided and two-sided confidence interval procedures for making successive comparisons between ordered treatments. Their procedures have important applications for problems where the treatment, can be assumed to satisfy a simple ordering, such as for a sequence of increasing dose-levels of a drug. The two-sided procedure provides both upper and lower bounds on the differences between Successive treatments, whereas the one-sided procedure only provides lower bounds on these differences. However, the one-sided procedure allows sharper inferences regarding which treatments can be declared to be better than their previous ones. In this paper we apply the results obtained in HAYTER, MIWA. and LIU (2000) to develop a new procedure which combines the good aspects of both the one-sided and the two-sided procedures. This new procedure maintains the inferential sensitivity of the one-sided procedure while also providing both upper and lower bounds on the differences between successive treatments. Some new critical points are needed which are tabulated for the balanced case where the sample sizes are all equal. The application of the new procedure is illustrated with an example.

Journal Title

Biometrical Journal

Volume

43

Issue/Number

5

Publication Date

1-1-2001

Document Type

Article

Language

English

First Page

533

Last Page

542

WOS Identifier

WOS:000171069400002

ISSN

0323-3847

Share

COinS