Title

Cyclin-dependent kinase homologues of Plasmodium falciparum

Authors

Authors

C. Doerig; J. Endicott;D. Chakrabarti

Abbreviated Journal Title

Int. J. Parasit.

Keywords

Plasmodium falciparum; malaria; cell cycle; cyclin-dependent kinases; CDK-ACTIVATING KINASE; XENOPUS SUC1/CKS PROTEIN; CRYSTAL-STRUCTURE; CELL-CYCLE; CDC2-RELATED KINASE; POSITIVE REGULATOR; INK4 INHIBITORS; BUDDING YEAST; COMPLEX; PHOSPHORYLATION; Parasitology

Abstract

The intraerythrocytic asexual cycle of the malarial parasite is complex and atypical: during schizogony the parasite undergoes multiple rounds of DNA replication and asynchronous nuclear division without cytokinesis. This cell cycle deviates from the classical eukaryotic cell cycle model where, 'DNA replicates only once per cell cycle'. A clear understanding of the molecular switches that control this unusual developmental cycle would be of great interest, both in terms of fundamental Plasmodium biology and in terms of novel potential drug target identification. In recent years considerable effort has been made to identify the malarial orthologues of the cyclin-dependent kinases, which are key regulators of the orderly progression of the eukaryotic cell cycle. This review focuses on the current state-of-knowledge of Plasmodium falciparum cyclin-dependent kinase-like kinases and their regulators. (C) 2002 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

Journal Title

International Journal for Parasitology

Volume

32

Issue/Number

13

Publication Date

1-1-2002

Document Type

Article; Proceedings Paper

Language

English

First Page

1575

Last Page

1585

WOS Identifier

WOS:000179898500007

ISSN

0020-7519

Share

COinS