Death and Baxes: mechanisms of lymphotrophic cytokines
Abbreviated Journal Title
RECEPTOR-DEFICIENT MICE; T-CELL DEVELOPMENT; FORKHEAD TRANSCRIPTION; FACTOR; GAMMA GENE REARRANGEMENT; APOPTOTIC PROTEIN BAK; FAMILY MEMBER; BIM; MHC CLASS-I; INTERLEUKIN-7 RECEPTOR; BCL-2 FAMILY; HOMEOSTATIC; PROLIFERATION; Immunology
In this review, we briefly cover the critical requirements for interleukin-7 (IL-7) in thymocyte development and peripheral T-cell homeostasis. Part of the IL-7 effect is antiapoptotic or 'trophic' and we have studied the intracellular pathways involved in lymphocyte survival and death regulated by this cytokine. We review the evidence for a role of the JAK signal transducers and activators of transcription protein (STAT) pathway and phosphoinositide 3-kinase (PI3K)-AKT pathways in survival. The death pathway following IL-7 withdrawal is discussed in terms of the balance of BCL-2 vs. BAX and other death proteins and the role of metabolic disturbances involving glucose metabolism and intracellular pH. The IL-7 survival and death pathways in lymphocytes may be representative of many trophic factors in different cell types; yet we conclude that much of the mechanism remains to be discovered.
"Death and Baxes: mechanisms of lymphotrophic cytokines" (2003). Faculty Bibliography 2000s. 3852.