Dietary, evolutionary, and modernizing influences on the prevalence of type 2 diabetes
Abbreviated Journal Title
Annu. Rev. Nutr.
obesity; Westernized diets; Syndrome X; dietary globalization; thrifty; genotypes; NUTRITION EXAMINATION SURVEYS; GENETICALLY UNKNOWN FOODS; BODY-MASS; INDEX; INSULIN-RESISTANCE; THRIFTY GENOTYPE; BIRTH-WEIGHT; FETAL-GROWTH; SOCIOECONOMIC-STATUS; NATIONAL-HEALTH; LIFE-STYLE; Nutrition & Dietetics
An evolutionary perspective is used to elucidate the etiology of the current epidemic of type 2 diabetes estimated at 151 million people. Our primate legacy, fossil hominid, and hunting-gathering lifestyles selected for adaptive metabolically thrifty genotypes and phenotypes are rendered deleterious through modem lifestyles that increase energy input and reduce output. The processes of modernization or globalization include the availability and abundance of calorically dense/low-fiber/high-glycemic foods and the adoption of sedentary Western lifestyles, leading to obesity among both children and adults in developed and developing countries. These trends are projected to continue for a number of decades.
Annual Review of Nutrition
"Dietary, evolutionary, and modernizing influences on the prevalence of type 2 diabetes" (2003). Faculty Bibliography 2000s. 3893.