Title

Visceral adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in women

Authors

Authors

B. J. Nicklas; Bwjh Penninx; A. S. Ryan; D. M. Berman; N. A. Lynch;K. E. Dennis

Comments

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Abbreviated Journal Title

Diabetes Care

Keywords

OBESE POSTMENOPAUSAL WOMEN; BODY-FAT DISTRIBUTION; ABDOMINAL FAT; CARDIOVASCULAR-DISEASE; COMPUTED-TOMOGRAPHY; INSULIN SENSITIVITY; MEN; OVERWEIGHT; ACCUMULATION; FOLLOW; Endocrinology & Metabolism

Abstract

OBJECTIVE - This study determined whether there is a critical level of visceral adipose tissue (VAT) associated with elevated coronary heart disease (CHD) risk factors in a cohort of women >45 years of age. RESEARCH DESIGN AND METHODS - Measurements of body composition (dual-energy X-ray absorptiometry), body fat distribution (computed tomography), fasting and 2-h postprandial (75-g) glucose concentrations, and fasting lipoprotein lipid and insulin concentrations were performed in 233 perimenopausal (9%) and postmenopausal women (age 59 - 5 years, 79% Caucasian, 16% on hormone replacement therapy). RESULTS - Women in the lowest VAT quintile (less than or equal to105 cm(2)) had higher concentrations of HDL and HDL2 cholesterol, lower LDL/HDL cholesterol ratios and triglyceride concentrations, and lower fasting glucose and insulin concentrations than women in the remaining four quintiles (P values <0.05-0.001). Women in the second lowest VAT quintile (106-139 cm(2)) had higher HDL and HDL2 cholesterol and lower LDL/HDL ratios than women with a VAT greater than or equal to163 cm(2) (P < 0.05). Logistic regression analyses showed that women with a VAT of 106-162 cm(2) are 2.5 times more likely to have a low HDL cholesterol (P < 0.05), while women with a VAT greater than or equal to163 cm(2) are 5.5 times more likely to have a low HDL cholesterol (P < 0.01) and similar to4.0 times more likely to have a high LDL/HDL ratio (P < 0.05) compared with women with a VAT less than or equal to105 cm(2). Women with a VAT greater than or equal to163 cm(2) are at a higher risk of having impaired glucose tolerance (P < 0.01). CONCLUSIONS - A VAT greater than or equal to106 cm(2) is associated with an elevated risk, and a VAT greater than or equal to163 cm(2) with an even greater risk, for these metabolic CHD risk factors compared with women with a VAT less than or equal to105 cm(2). These values may prove useful for defining "visceral obesity" and for identifying women most likely to benefit from preventative interventions.

Journal Title

Diabetes Care

Volume

26

Issue/Number

5

Publication Date

1-1-2003

Document Type

Article

Language

English

First Page

1413

Last Page

1420

WOS Identifier

WOS:000185505400015

ISSN

0149-5992

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