Title

Effects of MgO-CaO-P2O5-Na2O-based additives on mechanical and biological properties of hydroxyapatite

Authors

Authors

S. J. Kalita; D. Rokusek; S. Bose; H. L. Hosick;A. Bandyopadhyay

Comments

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Abbreviated Journal Title

J. Biomed. Mater. Res. Part A

Keywords

calcium phosphate; hydroxyapatite; sintering additives; bioactive; ceramics; bone cells; GLASS-REINFORCED HYDROXYAPATITE; SINTERING ADDITIVES; CERAMICS; BIOCERAMICS; COMPOSITES; PHOSPHATE; BONE; Engineering, Biomedical; Materials Science, Biomaterials

Abstract

In this research, we improved densification, hardness, and compression strength of synthetic hydroxyapatite (HAp) ceramics by introducing small quantities of MgO-CaO-P2O5-Na2O-based sintering additives. Biological properties of HAp were not altered by this procedure. Phase analyses were performed by using a Philips Xpert fully automated diffractometer with Co K-alpha radiation to understand the influence of additives on phase purity in the final products. All compositions were characterized at green and sintered densities to understand the influence of additives on densification. Some of the compositions showed >40% increase in Vickers microhardness compared with pure HAp processed under the same conditions. Improvement in compression strength was also detected in some compositions. In vitro biological testing used a modified human osteoblast cell line to test biocompatibility, cell attachment, and cell proliferation. All these compositions were nontoxic and biocompatible. Our results indicate that MgO-CaO-P2O5-Na2O-based sintering additives can be used to improve both mechanical and biological properties of HAp ceramics. (C) 2004 Wiley Periodicals, Inc.

Journal Title

Journal of Biomedical Materials Research Part A

Volume

71A

Issue/Number

1

Publication Date

1-1-2004

Document Type

Article

Language

English

First Page

35

Last Page

44

WOS Identifier

WOS:000223877000005

ISSN

0021-9304

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