Neural membrane field effects in a cytoskeleton corral: Microdomain regulation of impulse propagation
Abbreviated Journal Title
Int. J. Quantum Chem.
membranes; cytoskeleton; conduction failure; microdomains; rafts; ACTION-POTENTIAL PROPAGATION; SHAKER POTASSIUM CHANNEL; CELL-MEMBRANES; TRANSMEMBRANE SEGMENTS; LATERAL DIFFUSION; CONDUCTION BLOCK; HOP; DIFFUSION; K+ CHANNEL; MODEL; AXON; Chemistry, Physical; Mathematics, Interdisciplinary Applications; Physics, Atomic, Molecular & Chemical
This article proposes that electrostatic interaction between transiently polarized neural-membrane ethenes and charged residues of an unfolded ion-channel protein regulate channel closing and electrical signaling in neurons. Field effects are confined by a cytoskeleton corral that gates movement of membrane lipids from one corralled region to another. Cytoskeleton gating permits stepwise changes in the concentration of unsaturated lipids and thereby modulates ion-channel activity. The system is hypothesized to operate at axonal branch points where impulse conduction has a low safety factor. Throughout the discussion the A-current delayed-rectifier potassium channel is used as an example. Implications of the model for molecular networks are briefly discussed. (C) 2004 Wiley Periodicals, Inc.
International Journal of Quantum Chemistry
Article; Proceedings Paper
"Neural membrane field effects in a cytoskeleton corral: Microdomain regulation of impulse propagation" (2004). Faculty Bibliography 2000s. 4856.