Abbreviated Journal Title
PLoS One
Keywords
SERRATIA-MARCESCENS; GOLD NANOPARTICLES; RESISTANCE; NMR; Multidisciplinary Sciences
Abstract
Considering the increased incidence of bacterial infections and the emergence of multidrug resistant bacteria at the global level, we designed superparamagnetic iron oxide nanoparticles as nanosensors for the assessment of antimicrobial susceptibility through magnetic relaxation. In this report, we demonstrate that iron oxide nanosensors, either dextran-coated supplemented with Con A or silica-coated conjugated directly to Con A, can be used for the fast (1) quantification of polysaccharides, (2) assessment of metabolic activity and (3) determination of antimicrobial susceptibility in blood. The use of these polysaccharide nanosensors in the determination of antimicrobial susceptibility in the clinic or the field, and the utilization of these nanoprobes in pharmaceutical R&D are anticipated.
Journal Title
Plos One
Volume
3
Issue/Number
9
Publication Date
1-1-2008
Document Type
Article
Language
English
First Page
9
WOS Identifier
ISSN
1932-6203
Recommended Citation
Kaittanis, Charalambos; Nath, Sudip; and Perez, J. Manuel, "Rapid Nanoparticle-Mediated Monitoring of Bacterial Metabolic Activity and Assessment of Antimicrobial Susceptibility in Blood with Magnetic Relaxation" (2008). Faculty Bibliography 2000s. 503.
https://stars.library.ucf.edu/facultybib2000/503
Comments
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