Title

Rapid Nanoparticle-Mediated Monitoring of Bacterial Metabolic Activity and Assessment of Antimicrobial Susceptibility in Blood with Magnetic Relaxation

Authors

Authors

C. Kaittanis; S. Nath;J. M. Perez

Comments

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Abbreviated Journal Title

PLoS One

Keywords

SERRATIA-MARCESCENS; GOLD NANOPARTICLES; RESISTANCE; NMR; Multidisciplinary Sciences

Abstract

Considering the increased incidence of bacterial infections and the emergence of multidrug resistant bacteria at the global level, we designed superparamagnetic iron oxide nanoparticles as nanosensors for the assessment of antimicrobial susceptibility through magnetic relaxation. In this report, we demonstrate that iron oxide nanosensors, either dextran-coated supplemented with Con A or silica-coated conjugated directly to Con A, can be used for the fast (1) quantification of polysaccharides, (2) assessment of metabolic activity and (3) determination of antimicrobial susceptibility in blood. The use of these polysaccharide nanosensors in the determination of antimicrobial susceptibility in the clinic or the field, and the utilization of these nanoprobes in pharmaceutical R&D are anticipated.

Journal Title

Plos One

Volume

3

Issue/Number

9

Publication Date

1-1-2008

Document Type

Article

Language

English

First Page

9

WOS Identifier

WOS:000264431000001

ISSN

1932-6203

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