Development of controlled strength-loss resorbable beta-tricalcium phosphate bioceramic structures
Abbreviated Journal Title
Mater. Sci. Eng. C-Biomimetic Supramol. Syst.
beta-tricalcium phosphate; bioceramic; biocompatibility; sintering; additives; pressure-less sintering; biaxial flexural test; BIAXIAL FLEXURAL STRENGTH; GLASS-REINFORCED HYDROXYAPATITE; CERAMIC; MATERIALS; MECHANICAL-PROPERTIES; SINTERING ADDITIVES; ALPHA-TRICALCIUM; TCP CERAMICS; BONE; TRANSFORMATION; WHITLOCKITE; Materials Science, Multidisciplinary
Controlling the strength-loss rate during biodegradation is a bottleneck in developing viable resorbable ceramic implants. Resorbable betatricalcium phosphate (beta-TCP) bioceramic is known for its excellent biocompatibility. However, it exhibits poor sinterability and poor flexural strength. Here, we improved sintering behavior and biaxial flexural strength of beta-TCP bioceramic without altering its biocompatibility by introducing multi-oxide sintering additives, in small quantities. These additives could also tailor the rate of resorption and hardness deterioration of beta-TCP. A range of additives were prepared and introduced into beta-TCP powder. Resultant powders were uniaxially pressed and sintered at 1250 degrees C, in air. Considerable improvement in densification (up to 33%) and biaxial flexural strength (up to 43%) were achieved. X-ray powder diffraction (XRD) analysis confirmed that the additives didn't alter the phase purity. In vitro cytotoxicity and biocompatibility analyses were performed using a prostate cancer cell-line. Results showed that the doped and pure beta-TCP structures were non-toxic and biocompatible. (c) 2007 Elsevier B.V. All rights reserved.
Materials Science & Engineering C-Biomimetic and Supramolecular Systems
Article; Proceedings Paper
"Development of controlled strength-loss resorbable beta-tricalcium phosphate bioceramic structures" (2008). Faculty Bibliography 2000s. 504.