Title
Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M
Abbreviated Journal Title
J. Leukoc. Biol.
Keywords
knockout; bacteria; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; CATIONIC POLYPEPTIDES; MURAMIDASE; PEPTIDES; Cell Biology; Hematology; Immunology
Abstract
Lysozyme is a ubiquitous and abundant, cationic, antimicrobial polypeptide of leukocytes and epithelia, but its biological function in host defense is largely unexplored. To ascertain the role of lysozyme during bacterial infection of murine airways, we exposed the airways of lysozyme M-deficient (lys M-/-) mice to the pulmonary pathogen Pseudomonas aeruginosa and examined the host's response to infection. Despite partial compensation as a result of the appearance of lysozyme P in the infected airways of lys M-/- mice, these lys M-/- mice showed decreased clearance of P. aeruginosa compared with their lys M+/- or lys M+/+ littermates. Lysozyme contributes to optimal clearance of P. aeruginosa from the murine airways.
Journal Title
Journal of Leukocyte Biology
Volume
78
Issue/Number
5
Publication Date
1-1-2005
Document Type
Article
Language
English
First Page
1081
Last Page
1085
WOS Identifier
ISSN
0741-5400
Recommended Citation
"Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M" (2005). Faculty Bibliography 2000s. 5083.
https://stars.library.ucf.edu/facultybib2000/5083
Comments
Authors: contact us about adding a copy of your work at STARS@ucf.edu