Title

Fluorescent nanoparticle probes for cancer imaging

Authors

Authors

S. Santra; D. Dutta; G. A. Walter;B. M. Moudgil

Comments

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Abbreviated Journal Title

Technol. Cancer Res. Treat.

Keywords

SEMICONDUCTOR QUANTUM DOTS; DOPED SILICA NANOPARTICLES; POLYSTYRENE; LATEX-PARTICLES; IN-VIVO; GOLD NANOPARTICLES; CONTRAST AGENTS; ENERGY-TRANSFER; BIOLOGICAL APPLICATIONS; REVERSE MICROEMULSION; SILVER; NANOPARTICLES; Oncology

Abstract

Optical imaging technique has strong potential for sensitive cancer diagnosis, particularly at the early stage of cancer development. This is a sensitive, non-invasive, non-ionizing (clinically safe) and relatively inexpensive technique. Cancer imaging with optical technique however greatly relies upon the use of sensitive and stable optical probes. Unlike the traditional organic fluorescent probes, fluorescent nanoparticle probes such as dye-doped nanoparticles and quantum dots (Qdots) are bright and photostable. Fluorescent nanoparticle probes are shown to be very effective for sensitive cancer imaging with greater success in the cellular level. However, cancer imaging in an in vivo setup has been recently realized. There are several challenges in developing fluorescent nanoparticle probes for in vivo cancer imaging applications. In this review, we will discuss various aspects of nanoparticle design, synthesis, surface functionalization for bioconjugation and cancer cell targeting. A brief overview of in vivo cancer imaging with Qdots will also be presented.

Journal Title

Technology in Cancer Research & Treatment

Volume

4

Issue/Number

6

Publication Date

1-1-2005

Document Type

Review

Language

English

First Page

593

Last Page

602

WOS Identifier

WOS:000234550500003

ISSN

1533-0346

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