Schizophrenia and red light: fMRI evidence for a novel biobehavioral marker
Abbreviated Journal Title
Int. J. Neurosci.
biobehavioral marker; endophenotype; first-degree relatives; functional; magnetic resonance imaging; magnocellular visual pathway; red light; TRANSIENT/MAGNOCELLULAR VISUAL-SYSTEM; POSITRON-EMISSION-TOMOGRAPHY; HEMISPHERIC-ASYMMETRY; BACKGROUND COLOR; HUMAN BRAIN; M-CHANNELS; TELL; US; PERCEPTION; MOTION; CORTEX; Neurosciences
Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.
International Journal of Neuroscience
"Schizophrenia and red light: fMRI evidence for a novel biobehavioral marker" (2006). Faculty Bibliography 2000s. 5935.