Title

Influence of polymer-pore interactions on translocation

Authors

Authors

K. Luo; T. Ala-Nissila; S. C. Ying;A. Bhattacharya

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Phys. Rev. Lett.

Keywords

FACILITATED MEMBRANE-TRANSPORT; MONTE-CARLO-SIMULATION; POLYNUCLEOTIDE; MOLECULES; DNA TRANSPORT; NANOPORE; DRIVEN; DYNAMICS; CHANNEL; DISCRIMINATION; CHAIN; Physics, Multidisciplinary

Abstract

We investigate the influence of polymer-pore interactions on the translocation dynamics using Langevin dynamics simulations. An attractive interaction can greatly improve the translocation probability. At the same time, it also increases the translocation time slowly for a weak attraction while an exponential dependence is observed for a strong attraction. For fixed driving force and chain length the histogram of translocation time has a transition from Gaussian distribution to long-tailed distribution with increasing attraction. Under a weak driving force and a strong attractive force, both the translocation time and the residence time in the pore show a nonmonotonic behavior as a function of the chain length. Our simulations results are in good agreement with recent experimental data.

Journal Title

Physical Review Letters

Volume

99

Issue/Number

14

Publication Date

1-1-2007

Document Type

Article

Language

English

First Page

4

WOS Identifier

WOS:000249974000078

ISSN

0031-9007

Share

COinS