Title

Heteropolymer translocation through nanopores

Authors

Authors

K. F. Luo; T. Ala-Nissila; S. C. Ying;A. Bhattacharya

Comments

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Abbreviated Journal Title

J. Chem. Phys.

Keywords

MONTE-CARLO-SIMULATION; SOLID-STATE NANOPORE; POLYMER TRANSLOCATION; POLYNUCLEOTIDE MOLECULES; DNA TRANSLOCATION; MEMBRANE CHANNEL; DYNAMICS; DRIVEN; PROTEINS; DISCRIMINATION; Physics, Atomic, Molecular & Chemical

Abstract

The authors investigate the translocation dynamics of heteropolymers driven through a nanopore using a constant temperature Langevin thermostat. Specifically, they consider heteropolymers consisting of two types of monomers labeled A and B, which are distinguished by the magnitude of the driving force that they experience inside the pore. From a series of studies on polymers with sequences A(m)B(n) the authors identify both universal as well as specific sequence properties of the translocating chains. They find that the scaling of the average translocation time as a function of the chain length N remains unaffected by the heterogeneity, while the residence time of each bead is a strong function of the sequence for short repeat units. They further discover that for a symmetric heteropolymer A(n)B(n) of fixed length, the pattern exhibited by the residence times of the individual monomers has striking similarity with a double slit interference pattern where the total number of repeat units N/2n controls the number of interference fringes. These results are relevant for designing nanopore based sequencing techniques. (c) 2007 American Institute of Physics.

Journal Title

Journal of Chemical Physics

Volume

126

Issue/Number

14

Publication Date

1-1-2007

Document Type

Article

Language

English

First Page

7

WOS Identifier

WOS:000245691200059

ISSN

0021-9606

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