Title

Prostate cancer risk and ESR1 TA, ESR2 CA repeat polymorphisms

Authors

Authors

M. H. McIntyre; P. W. Kantoff; M. J. Stampfer; L. A. Mucci; D. Parslow; H. Li; J. M. Gaziano; M. Abe;J. Ma

Comments

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Abbreviated Journal Title

Cancer Epidemiol. Biomarkers Prev.

Keywords

ESTROGEN-RECEPTOR-ALPHA; BONE-MINERAL DENSITY; CORONARY-ARTERY-DISEASE; GENE POLYMORPHISMS; ENDOMETRIAL CANCER; POSTMENOPAUSAL WOMEN; BETA-GENE; ASSOCIATION; ANDROGEN; HAPLOTYPES; Oncology; Public, Environmental & Occupational Health

Abstract

Background: Experimental evidence has suggested that estrogen receptor alpha (coded by the gene ESR1) might increase prostate cancer risk, whereas estrogen receptor beta (coded by the gene ESR2) might reduce prostate cancer risk. Methods: We investigated the relationship with prostate cancer risk of both a TA repeat polymorphism in the ESR1 5' region, ESR1 (TA)(n), and with a CA repeat polymorphism in intron 5 of ESR2, ESR2 (CA)(n), in a case-control study (545 cases and 674 controls) nested in the Physicians' Health Study. Results: Prostate cancer risk was highest for carriers of ESR1 (TA)(24) and ESR1 (TA)(25). Replacing one modal ESR1 (TA)(14) allele with one ESR1 (TA)(24) allele yielded an odds ratio of 1.42 (95% confidence interval, 1.00-2.00; P = 0.05). Replacing one ESR1 (TA)(14) allele with one ESR1 (TA)(25) allele yielded an odds ratio of 2.10 (95% confidence interval, 1.15-3.84; P = 0.02). ESR2 (CA), showed no effects on prostate cancer risk. Conclusions: The ESR1 (TA)(n) polymorphism might play a role in prostate cancer risk.

Journal Title

Cancer Epidemiology Biomarkers & Prevention

Volume

16

Issue/Number

11

Publication Date

1-1-2007

Document Type

Article

Language

English

First Page

2233

Last Page

2236

WOS Identifier

WOS:000251123500012

ISSN

1055-9965

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