STAT3 as a target for inducing apoptosis in solid and hematological tumors
Abbreviated Journal Title
STAT3; DNA-binding; apoptosis; small-molecule inhibitors; cell growth; human tumors; BREAST-CANCER CELLS; HUMAN PANCREATIC-CANCER; JANUS KINASE/SIGNAL; TRANSDUCER; CONSTITUTIVE SIGNAL TRANSDUCER; ANAPLASTIC LYMPHOMA KINASE; RECEPTOR TYROSINE KINASES; ENDOTHELIAL GROWTH-FACTOR; POTENT; ANTITUMOR-ACTIVITY; NON-HODGKINS-LYMPHOMA; DNA-BINDING ACTIVITY; Cell Biology
Studies in the past few years have provided compelling evidence for the critical role of aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant transformation and tumorigenesis. Thus, it is now generally accepted that STAT3 is one of the critical players in human cancer formation and represents a valid target for novel anticancer drug design. This review focuses on aberrant STAT3 and its role in promoting tumor cell survival and supporting the malignant phenotype. A brief evaluation of the current strategies targeting STAT3 for the development of novel anticancer agents against human tumors harboring constitutively active STAT3 will also be presented.
"STAT3 as a target for inducing apoptosis in solid and hematological tumors" (2008). Faculty Bibliography 2000s. 985.