Colistin Dosing and Nephrotoxicity in a Large Community Teaching Hospital
Abbreviated Journal Title
Antimicrob. Agents Chemother.
CRITICALLY-ILL PATIENTS; GRAM-NEGATIVE BACTERIA; INTRAVENOUS COLISTIN; MULTIDRUG-RESISTANT; INFECTIONS; METHANESULFONATE; THERAPY; PHARMACOKINETICS; CLASSIFICATION; TOXICITY; Microbiology; Pharmacology & Pharmacy
Thirty adult patients who received intravenous colistin (5.1 +/- 2.4 mg/kg/day) were reviewed to evaluate dosing with respect to nephrotoxicity, which occurred in 10 (33%) patients within the first 5 days of treatment. Excessive colistin dosing was frequent (47%), often (71%) resulted from the use of actual body weight in obese patients, and was associated with higher rates of nephrotoxicity (80% versus 30%, P = 0.019).
Antimicrobial Agents and Chemotherapy
"Colistin Dosing and Nephrotoxicity in a Large Community Teaching Hospital" (2010). Faculty Bibliography 2010s. 108.