Title

Colistin Dosing and Nephrotoxicity in a Large Community Teaching Hospital

Authors

Authors

C. A. DeRyke; A. J. Crawford; N. Uddin;M. R. Wallace

Comments

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Abbreviated Journal Title

Antimicrob. Agents Chemother.

Keywords

CRITICALLY-ILL PATIENTS; GRAM-NEGATIVE BACTERIA; INTRAVENOUS COLISTIN; MULTIDRUG-RESISTANT; INFECTIONS; METHANESULFONATE; THERAPY; PHARMACOKINETICS; CLASSIFICATION; TOXICITY; Microbiology; Pharmacology & Pharmacy

Abstract

Thirty adult patients who received intravenous colistin (5.1 +/- 2.4 mg/kg/day) were reviewed to evaluate dosing with respect to nephrotoxicity, which occurred in 10 (33%) patients within the first 5 days of treatment. Excessive colistin dosing was frequent (47%), often (71%) resulted from the use of actual body weight in obese patients, and was associated with higher rates of nephrotoxicity (80% versus 30%, P = 0.019).

Journal Title

Antimicrobial Agents and Chemotherapy

Volume

54

Issue/Number

10

Publication Date

1-1-2010

Document Type

Article

Language

English

First Page

4503

Last Page

4505

WOS Identifier

WOS:000281907200065

ISSN

0066-4804

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