Title

Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions

Authors

Authors

J. A. Drewry; S. Fletcher; P. B. Yue; D. Marushchak; W. Zhao; S. Sharmeen; X. L. Zhang; A. D. Schimmer; C. Gradinaru; J. Turkson;P. T. Gunning

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Chem. Commun.

Keywords

MOLECULAR RECOGNITION; ARTIFICIAL RECEPTORS; CELL-TRANSFORMATION; SIGNAL; TRANSDUCER; GENE-REGULATION; STAT3; CANCER; TRANSCRIPTION-3; INHIBITION; ACTIVATION; Chemistry, Multidisciplinary

Abstract

We report the first application of coordination complexes as functional proteomimetics of the Src homology 2 (SH2) phosphopeptide-binding domain. As a proof-of-concept, functionalized bis-dipicolylamine (BDPA) copper(II) complexes are shown to disrupt oncogenic Stat3-Stat3 protein complexes and elicit promising anti-tumour activity.

Journal Title

Chemical Communications

Volume

46

Issue/Number

6

Publication Date

1-1-2010

Document Type

Article

DOI Link

http://dx.doi.org/10.1039/b919608k

Language

English

First Page

892

Last Page

894

WOS Identifier

WOS:000274070800012

ISSN

1359-7345

Recommended Citation

"Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions" (2010). Faculty Bibliography 2010s. 121.
https://stars.library.ucf.edu/facultybib2010/121