Title

1 ACUTE L-ALANYL-L-GLUTAMINE INGESTION DURING SHORT DURATION, HIGH INTENSITY EXERCISE AND A MILD HYDRATION STRESS

Authors

Authors

J. R. Hoffman; N. A. Ratamess; J. Kang; S. L. Rashti; N. Kelly; A. M. Gonzalez; M. Stec; S. Anderson; B. L. Bailey; L. M. Yamamoto; L. L. Hom; B. R. Kupchak;C. M. Maresh

Comments

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Abbreviated Journal Title

Kinesiology

Keywords

endocrine response; immune response; fluid regulatory hormones; electrolytes; anabolic hormones; TOTAL PARENTERAL-NUTRITION; GROWTH-HORMONE RESPONSE; WATER-ABSORPTION; INFLAMMATORY MEDIATORS; VASOPRESSIN RESPONSES; PLASMA TESTOSTERONE; RESISTANCE EXERCISE; EXHAUSTIVE EXERCISE; ENDOCRINE RESPONSES; OXIDATIVE; STRESS; Rehabilitation; Sport Sciences

Abstract

The effect of acute L-alanyl-L-glutamine (AG) ingestion on selected hormonal and electrolyte measures was examined during repetitive, short duration, high intensity exercise with mild hypohydration. Subjects (20.3 +/- 1.1 yrs; 180.3 +/- 10.4 cm; 83.1 +/- 14.0 kg; 11.6 +/- 3.6% body fat) reported to the Human Performance Laboratory on four occasions. During each trial subjects were hypohydrated to -2.5% of their baseline body mass. During one trial (DHY) subjects rested in a recumbent position for 45 minutes before commencing the exercise session. During the other three trials subjects were rehydrated to 1.5% of their baseline body mass, before exercise, by drinking water only (W), or with two different doses of AG - a low dose (LDAG: 0.05 g.kg(-1)) and a high dose (HDAG: 0.2 g.kg(-1)). The exercise protocol consisted of ten 10-second sprints on a cycle ergometer with a 1-min rest between each sprint. Blood draws were collected once the subject achieved the desired level of hypohydration, immediately pre-exercise, immediately post-exercise, and 24 hrs post-exercise. Blood samples were analyzed for glutamine, potassium, sodium, aldosterone, arginine vasopressin, C-reactive protein, interleukin-6, malondialdehyde, testosterone, cortisol, ACTH, and growth hormone. The area under the curve (AUC) analysis demonstrated significantly greater sodium concentrations for DHY compared to all other trials. The AUC analysis for aldosterone showed significantly lower concentrations at LDAG compared to DHY. No other differences between trials were observed in any other hormonal or biochemical responses. AG ingestion during a short duration, anaerobic exercise and mild hypohydration stress had a limited effect on selected hormonal and biochemical measures.

Journal Title

Kinesiology

Volume

43

Issue/Number

2

Publication Date

1-1-2011

Document Type

Article

Language

English

First Page

125

Last Page

136

WOS Identifier

WOS:000306676700001

ISSN

1331-1441

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