Title
Computational analysis and structure predictions of CHH-related peptides from Litopenaeus vannamei
Abbreviated Journal Title
Integr. Biol.
Keywords
CRUSTACEAN HYPERGLYCEMIC HORMONE; MOLT-INHIBITING HORMONE; AMINO-ACID-SEQUENCE; MOLECULAR CHARACTERIZATION; HOMARUS-AMERICANUS; CARCINUS-MAENAS; CDNA CLONING; PROTEIN; SHRIMP; EXPRESSION; Cell Biology
Abstract
The crustaceans produce several related peptides that belong to the crustacean hyperglycemic hormone (CHH) family. While these peptides have similar amino acid sequences, they have diverse biological functions that must arise, in part, from differences in the 3D shape of these peptides. However, it is generally accepted that peptides with a high degree of sequence similarity also have a similar 3-D structure. We used the solution structure of one peptide in the crustacean hyperglycemic hormone family, the molt-inhibiting hormone of the kuruma prawn (Marsupenaeus japonicus), to predict the shape of the five known peptides related to CHH in the Pacific white shrimp, Litopenaeus vannamei. The high similarity of the 3-D structures of these peptides suggests a common fold for the entire family. Nevertheless, minor differences in the shape of these peptides were observed, which may be the basis for their different biological properties.
Journal Title
Integrative Biology
Volume
3
Issue/Number
3
Publication Date
1-1-2011
Document Type
Article
DOI Link
Language
English
First Page
218
Last Page
224
WOS Identifier
ISSN
1757-9694
Recommended Citation
"Computational analysis and structure predictions of CHH-related peptides from Litopenaeus vannamei" (2011). Faculty Bibliography 2010s. 1700.
https://stars.library.ucf.edu/facultybib2010/1700
Comments
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