Stem cells in the diabetic infarcted heart
Abbreviated Journal Title
Heart Fail. Rev.
Diabetes; Embryonic stem cells; Myocardial infarction; Oxidative stress; Hyperglycemia; ACUTE MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; ANIMAL-MODELS; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; CARDIAC-FUNCTION; RAT MODEL; Cardiac & Cardiovascular Systems
Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant advances in pharmacological interventions and surgical techniques, the disease progression leading to diabetic end-stage heart failure remains very high. Recently, cell therapy has gained much attention as an alternative approach to treat various heart diseases. However, transplanted stem cell studies in diabetic animal models are very limited. In this review, we discuss the pathogenesis of the diabetic infarcted heart and the potential of stem cell therapy to repair and regenerate.
Heart Failure Reviews
"Stem cells in the diabetic infarcted heart" (2010). Faculty Bibliography 2010s. 189.