Title
Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria
Abbreviated Journal Title
Biomaterials
Keywords
Tubby mouse; Nanoceria; Antioxidant; Gene expression; Retinal; degeneration; Longevity; ENDOPLASMIC-RETICULUM STRESS; CERIUM OXIDE NANOPARTICLES; OXIDATIVE; STRESS; RETINAL DEGENERATION; CELL-DEATH; DRUG-DELIVERY; OPSIN; MISLOCALIZATION; MACULAR DEGENERATION; RETINITIS-PIGMENTOSA; REDOX STATE; Engineering, Biomedical; Materials Science, Biomaterials
Abstract
We previously reported that nanoceria can slow retinal degeneration in the tubby mouse for two weeks by multiple systemic injections. However, the long-term protection of retinal structure and function by directly deliver of nanoceria to the eye had not been explored. In this study, 172 ng of nanoceria in 1 mu l saline (1 mM) were intravitreally injected into tubby P7 pups and assays were performed at P28, P49, P80 and P120. The expression of antioxidant associated genes and photoreceptor-specific genes was significantly up regulated, the mislocalization of rod and cone opsins was decreased, and retinal structure and function were protected. These findings demonstrate that nanoceria can function as catalytic antioxidants in vivo and may be broad spectrum therapeutic agents for multiple types of ocular diseases. (C) 2012 Elsevier Ltd. All rights reserved.
Journal Title
Biomaterials
Volume
33
Issue/Number
34
Publication Date
1-1-2012
Document Type
Article
Language
English
First Page
8771
Last Page
8781
WOS Identifier
ISSN
0142-9612
Recommended Citation
"Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria" (2012). Faculty Bibliography 2010s. 2345.
https://stars.library.ucf.edu/facultybib2010/2345
Comments
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