Title

Emerging nanotechnology-based strategies for the identification of microbial pathogenesis

Authors

Authors

C. Kaittanis; S. Santra;J. M. Perez

Comments

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Abbreviated Journal Title

Adv. Drug Deliv. Rev.

Keywords

Pathogen detection; Deployable sensors; Toxin detection; Bacterial drug; resistance; Nanosensors; Nanodiagnostics; ESCHERICHIA-COLI O157-H7; STAPHYLOCOCCAL-ENTEROTOXIN-B; SHIGA-LIKE; TOXIN; GOLD NANOPARTICLES; RAPID DETECTION; BACILLUS-ANTHRACIS; QUANTUM; DOTS; MAGNETIC-RELAXATION; FLOW-CYTOMETRY; ANTIMICROBIAL SUSCEPTIBILITY; Pharmacology & Pharmacy

Abstract

Infectious diseases are still a major healthcare problem. From food intoxication and contaminated water, to hospital-acquired diseases and pandemics, infectious agents cause disease throughout the world. Despite advancements in pathogens' identification, some of the gold-standard diagnostic methods have limitations, including laborious sample preparation, bulky instrumentation and slow data readout. In addition, new field-deployable diagnostic modalities are urgently needed in first responder and point-of-care applications. Apart from compact, these sensors must be sensitive, specific, robust and fast, in order to facilitate detection of the pathogen even in remote rural areas. Considering these characteristics, researchers have utilized innovative approaches by employing the unique properties of nanomaterials in order to achieve detection of infectious agents, even in complex media like blood. From gold nanoparticles and their plasmonic shifts to iron oxide nanoparticles and changes in magnetic properties, detection of pathogens, toxins, antigens and nucleic acids has been achieved with impressive detection thresholds. Additionally, as bacteria become resistant to antibiotics, nanotechnology has achieved the rapid determination of bacterial drug susceptibility and resistance using novel methods, such as amperometry and magnetic relaxation. Overall, these promising results hint to the adoption of nanotechnology-based diagnostics for the diagnosis of infectious diseases in diverse settings throughout the globe, preventing epidemics and safeguarding human and economic wellness. (C) 2009 Elsevier B.V. All rights reserved.

Journal Title

Advanced Drug Delivery Reviews

Volume

62

Issue/Number

4-5

Publication Date

1-1-2010

Document Type

Review

Language

English

First Page

408

Last Page

423

WOS Identifier

WOS:000276123400004

ISSN

0169-409X

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