Authors

V. Shah; S. Shah; H. Shah; F. J. Rispoli; K. T. McDonnell; S. Workeneh; A. Karakoti; A. Kumar;S. Seal

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Abbreviated Journal Title

PLoS One

Keywords

ESCHERICHIA-COLI; DEXTRAN; TOXICITY; INTERNALIZATION; OPTIMIZATION; ANTIOXIDANT; NANOCERIA; DESIGN; MEDIA; CELLS; Multidisciplinary Sciences

Abstract

Cerium oxide nanoparticles have found numerous applications in the biomedical industry due to their strong antioxidant properties. In the current study, we report the influence of nine different physical and chemical parameters: pH, aeration and, concentrations of MgSO4, CaCl2, KCl, natural organic matter, fructose, nanoparticles and Escherichia coli, on the antibacterial activity of dextran coated cerium oxide nanoparticles. A least-squares quadratic regression model was developed to understand the collective influence of the tested parameters on the anti-bacterial activity and subsequently a computer-based, interactive visualization tool was developed. The visualization allows us to elucidate the effect of each of the parameters in combination with other parameters, on the antibacterial activity of nanoparticles. The results indicate that the toxicity of CeO2 NPs depend on the physical and chemical environment; and in a majority of the possible combinations of the nine parameters, non-lethal to the bacteria. In fact, the cerium oxide nanoparticles can decrease the anti-bacterial activity exerted by magnesium and potassium salts.

Journal Title

Plos One

Volume

7

Issue/Number

10

Publication Date

1-1-2012

Document Type

Article

Language

English

First Page

13

WOS Identifier

WOS:000310262500021

ISSN

1932-6203

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