Title
Rare earth oxides as nanoadditives in 3-D nanocomposite scaffolds for bone regeneration
Abbreviated Journal Title
J. Mater. Chem.
Keywords
IONIC-DISSOLUTION PRODUCTS; BIOMEDICAL APPLICATIONS; CERIA; NANOPARTICLES; GENE-EXPRESSION; GEL-GLASS; NANOCERIA; OSTEOBLASTS; DIFFERENTIATION; ANTIOXIDANT; CELLS; Chemistry, Physical; Materials Science, Multidisciplinary
Abstract
Nanocomposite scaffolds of bioactive glass foams containing tailor made rare earth oxide (i.e. nanoceria) additives were demonstrated to enhance the production of collagen by HMSCs (Human Mesenchymal Stem Cells) compared to bioactive glass scaffolds without nanoceria. The addition of osteogenic supplements was not required for this to occur. Two different preparations of nanoceria were successfully incorporated in 3-D bioactive glass foam scaffolds and were compared with bioactive scaffolds without nanoceria. The nanoparticles had individual particle sizes of 3-5 nm while the agglomerate size varied from 5-15 nm. Preliminary investigations show that nanoceria is non toxic to the cells. After 10 days of culture, nanoceria containing scaffolds showed enhanced osteoblastic differentiation of HMSCs and collagen production compared to the scaffolds without nanoceria even in the absence of any osteogenic supplements (i.e. ascorbic acid, dexamethasone and beta-glycerophosphate). This could be due to the incorporation of nanoceria, which acts as an oxygen buffer thereby regulating the differentiation of HMSCs. Further investigations are currently underway to determine the role of the nanoceria controlled oxygen buffering on the HMSC differentiation.
Journal Title
Journal of Materials Chemistry
Volume
20
Issue/Number
40
Publication Date
1-1-2010
Document Type
Article
DOI Link
Language
English
First Page
8912
Last Page
8919
WOS Identifier
ISSN
0959-9428
Recommended Citation
"Rare earth oxides as nanoadditives in 3-D nanocomposite scaffolds for bone regeneration" (2010). Faculty Bibliography 2010s. 337.
https://stars.library.ucf.edu/facultybib2010/337
Comments
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