The Bis(Indolyl)Imidazole Alkaloid Nortopsentin A Exhibits Antiplasmodial Activity
Abbreviated Journal Title
Antimicrob. Agents Chemother.
PLASMODIUM-FALCIPARUM; MANZAMINE; SPONGE; CYCLE; DNA; Microbiology; Pharmacology & Pharmacy
A library of enriched marine natural product fractions was screened for their antiplasmodial activity using a SYBR green I fluorescence-based assay. Fractions derived from a sponge of the genus Spongosorites exhibited potent inhibition of Plasmodium falciparum growth. This genus of sponge has been reported to contain the nortopsentin and topsentin class of bis-indole imidazole alkaloids. This is the first report of nortopsentin A inhibiting parasite growth at the trophozoite stage at submicromolar 50% inhibitory concentrations (IC50).
Antimicrobial Agents and Chemotherapy
"The Bis(Indolyl)Imidazole Alkaloid Nortopsentin A Exhibits Antiplasmodial Activity" (2013). Faculty Bibliography 2010s. 3609.