Abbreviated Journal Title
Antimicrob. Agents Chemother.
Keywords
PLASMODIUM-FALCIPARUM; MANZAMINE; SPONGE; CYCLE; DNA; Microbiology; Pharmacology & Pharmacy
Abstract
A library of enriched marine natural product fractions was screened for their antiplasmodial activity using a SYBR green I fluorescence-based assay. Fractions derived from a sponge of the genus Spongosorites exhibited potent inhibition of Plasmodium falciparum growth. This genus of sponge has been reported to contain the nortopsentin and topsentin class of bis-indole imidazole alkaloids. This is the first report of nortopsentin A inhibiting parasite growth at the trophozoite stage at submicromolar 50% inhibitory concentrations (IC50).
Journal Title
Antimicrobial Agents and Chemotherapy
Volume
57
Issue/Number
5
Publication Date
1-1-2013
Document Type
Article
Language
English
First Page
2362
Last Page
2364
WOS Identifier
ISSN
0066-4804
Recommended Citation
Alvardo, Stephenie; Roberts, Bracken F.; Wright, Amy E.; and Chakrabarti, Debopam, "The Bis(Indolyl)Imidazole Alkaloid Nortopsentin A Exhibits Antiplasmodial Activity" (2013). Faculty Bibliography 2010s. 3609.
https://stars.library.ucf.edu/facultybib2010/3609
Comments
Authors: contact us about adding a copy of your work at STARS@ucf.edu