Title

The Bis(Indolyl)Imidazole Alkaloid Nortopsentin A Exhibits Antiplasmodial Activity

Authors

Authors

S. Alvarado; B. F. Roberts; A. E. Wright;D. Chakrabarti

Comments

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Abbreviated Journal Title

Antimicrob. Agents Chemother.

Keywords

PLASMODIUM-FALCIPARUM; MANZAMINE; SPONGE; CYCLE; DNA; Microbiology; Pharmacology & Pharmacy

Abstract

A library of enriched marine natural product fractions was screened for their antiplasmodial activity using a SYBR green I fluorescence-based assay. Fractions derived from a sponge of the genus Spongosorites exhibited potent inhibition of Plasmodium falciparum growth. This genus of sponge has been reported to contain the nortopsentin and topsentin class of bis-indole imidazole alkaloids. This is the first report of nortopsentin A inhibiting parasite growth at the trophozoite stage at submicromolar 50% inhibitory concentrations (IC50).

Journal Title

Antimicrobial Agents and Chemotherapy

Volume

57

Issue/Number

5

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

2362

Last Page

2364

WOS Identifier

WOS:000317467600047

ISSN

0066-4804

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