Title

Mitigation of endometriosis using regenerative cerium oxide nanoparticles

Authors

Authors

K. Chaudhury; K. N. Babu; A. K. Singh; S. Das; A. Kumar;S. Seal

Comments

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Abbreviated Journal Title

Nanomed.-Nanotechnol. Biol. Med.

Keywords

Cerium oxide nanoparticles; Antioxidant; Endometriosis; Anti-angiogenesis; LIVING HUMAN OOCYTES; OXIDATIVE-STRESS; MEIOTIC SPINDLE; MOUSE MODEL; ANTIOXIDANT; POLSCOPE; WOMEN; CARDIOMYOPATHY; VISUALIZATION; ANGIOGENESIS; Nanoscience & Nanotechnology; Medicine, Research & Experimental

Abstract

Cerium oxide nanoparticles (nanoceria) have recently received attention from the scientific community due to their unique free radicals (specially superoxide radical and hydrogen peroxide) scavenging property in biological system, both in vitro and in vivo. It is suggested that free radicals play an important role in the pathogenesis of endometriosis. In this study we have shown that nanoceria mitigate the endometrial lesions induced in mice model by decreasing oxidative stress and inhibiting angiogenesis. Moreover, nanoceria were also observed to protect endometriosis-related adverse effects on the oocytes, which is critical for successful pregnancy. Summarizing, nanoceria have shown promising efficacy against endometriosis related pathogenesis. From the Clinical Editor: Free radicals have been implemented in the pathogenesis of endometriosis. In a murine model the authors demonstrated successful treatment of endometriosis with nanoceria, and protection of endometriosis-related adverse effects on the oocytes, paving the way to potential clinical translational applications in the future. (C) 2013 Elsevier Inc. All rights reserved.

Journal Title

Nanomedicine-Nanotechnology Biology and Medicine

Volume

9

Issue/Number

3

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

439

Last Page

448

WOS Identifier

WOS:000316728800014

ISSN

1549-9634

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