Title

Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing

Authors

Authors

S. Chigurupati; M. R. Mughal; E. Okun; S. Das; A. Kumar; M. McCaffery; S. Seal;M. P. Mattson

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Biomaterials

Keywords

Cerium oxide nanoparticles; Vascular endothelial cells; Keratinocytes; Fibroblasts; Wound healing; Oxidative stress; TUBBY MICE; NANOCERIA; ANTIOXIDANT; ANGIOGENESIS; DEGENERATION; MODULATION; PROTECTION; PROTEINS; REPAIR; Engineering, Biomedical; Materials Science, Biomaterials

Abstract

Rapid and effective wound healing requires a coordinated cellular response involving fibroblasts, keratinocytes and vascular endothelial cells (VECs). Impaired wound healing can result in multiple adverse health outcomes and, although antibiotics can forestall infection, treatments that accelerate wound healing are lacking. We now report that topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs. The Nanoceria penetrated into the wound tissue and reduced oxidative damage to cellular membranes and proteins, suggesting a therapeutic potential for topical treatment of wounds with antioxidant nanoparticles. Published by Elsevier Ltd.

Journal Title

Biomaterials

Volume

34

Issue/Number

9

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

2194

Last Page

2201

WOS Identifier

WOS:000315179200005

ISSN

0142-9612

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