Title

Retrograde Versus Antegrade Nerve Sparing During Robot-assisted Radical Prostatectomy: Which Is Better for Achieving Early Functional Recovery?

Authors

Authors

Y. H. Ko; R. F. Coelho; A. Sivaraman; O. Schatloff; S. Chauhan; H. M. Abdul-Muhsin; R. J. V. Carrion; K. J. Palmer; J. Cheon;V. R. Patel

Comments

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Abbreviated Journal Title

Eur. Urol.

Keywords

Nerve sparing; Robot assisted radical prostatectomy; Erectile; dysfunction; Incontinence; SEXUAL FUNCTION; RETROPUBIC PROSTATECTOMY; SURGICAL TECHNIQUE; CONTINENCE; PRESERVATION; OUTCOMES; SURGEON; QUALITY; FASCIA; Urology & Nephrology

Abstract

Background: Although the retrograde approach to nerve sparing (NS) aimed at maximizing NS during robot-assisted radical prostatectomy (RARP) has been described, its significant benefits compared to the antegrade approach have not yet been investigated. Objective: To evaluate the impact of NS approaches on perioperative, pathologic, and functional outcomes. Design, setting, and participants: Five hundred one potent (Sexual Health Inventory for Men [SHIM] score >21) men underwent bilateral full NS and were followed up for a minimum of 1 yr. After propensity score matching, 344 patients were selected and were then categorized into two groups. Surgical procedure: RARP with antegrade NS (n = 172) or RARP with retrograde NS (n = 172). Outcome measurements and statistical analysis: Functional outcomes were assessed using validated questionnaires. Multivariable logistic regression models were applied. Results and limitations: Positive margin rates were similar (11.1% vs 6.9%; p = 0.192), and no correlation with the NS approach was found on regression analysis. At 3, 6, and 9 mo, the potency rate was significantly higher in the retrograde approach (65% vs 80.8% and 72.1% vs 90.1% and 85.3% vs 92.9%, respectively). The multivariable model indicated that the NS approach was an independent predictor for potency recovery at 3, 6, and 9 mo, along with age, gland size, and hyperlipidemia. After adjusting for these predictors, the hazard ratio (HR) for the retrograde relative to the antegrade approach was 2.462 (95% confidence interval [CI], 1.482-4.089; p = 0.001) at 3, 4.024 (95% CI, 2.171-7.457; p < 0.001) at 6, and 2.145 (95% CI, 1.019-4.514; p = 0.044) at 9 mo. Regarding continence, the recovery rates at each time point and the mean time to regaining it were similar, and the method of NS had no effect on multivariable analysis. The absence of randomization is a major limitation of this study. Conclusions: In patients with normal erectile function who underwent bilateral full NS, a retrograde NS approach facilitated early recovery of potency compared to that with an antegrade NS approach without compromising cancer control. (C) 2012 Published by Elsevier B. V. on behalf of European Association of Urology.

Journal Title

European Urology

Volume

63

Issue/Number

1

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

169

Last Page

177

WOS Identifier

WOS:000312004100031

ISSN

0302-2838

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