Title

Interplay between Velocity and Travel Distance of Kinesin-based Transport in the Presence of Tau

Authors

Authors

J. Xu; S. J. King; M. Lapierre-Landry;B. Nemec

Comments

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Abbreviated Journal Title

Biophys. J.

Keywords

TUG-OF-WAR; MICROTUBULE SURFACE; MOTOR; DYNEIN; PROCESSIVITY; PROTEINS; LATTICE; Biophysics

Abstract

Although the disease-relevant microtubule-associated protein tau is known to severely inhibit kinesin-based transport in vitro, the potential mechanisms for reversing this detrimental effect to maintain healthy transport in cells remain unknown. Here we report the unambiguous upregulation of multiple-kinesin travel distance despite the presence of tau, via decreased single-kinesin velocity. Interestingly, the presence of tau also modestly reduced cargo velocity in multiple-kinesin transport, and our stochastic simulations indicate that the tau-mediated reduction in single-kinesin travel underlies this observation. Taken together, our observations highlight a nontrivial interplay between velocity and travel distance for kinesin transport, and suggest that single-kinesin velocity is a promising experimental handle for tuning the effect of tau on multiple-kinesin travel distance.

Journal Title

Biophysical Journal

Volume

105

Issue/Number

10

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

L23

Last Page

L25

WOS Identifier

WOS:000327285100001

ISSN

0006-3495

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