Title

Non-phosgene route to unsymmetrical ureas from N-Cbz-alpha-amino acid amides

Authors

Authors

E. H. G. Zadeh; N. E. Abo-Dya; A. C. Sotuyo; I. Ghiviriga;C. D. Hall

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Tetrahedron Lett.

Keywords

Urea synthesis; Rearrangement; Non-phosgene; alpha-Amino acid amides; BETA-SHEET LIGANDS; ALZHEIMERS-DISEASE; CARBON-DIOXIDE; OXIDATIVE; CARBONYLATION; TETRASUBSTITUTED UREAS; DERIVATIVES; EFFICIENT; ANTAGONISTS; INHIBITORS; DESIGN; Chemistry, Organic

Abstract

A convenient method toward the synthesis of alpha-amino acid-derived unsymmetrical ureas 2 is described herein. This route involves an interesting rearrangement of amides of N-Cbz-alpha-amino acids 1, which pre-sumably entails the intermediacy of hydantoins that is followed by hydrolysis to afford unsymmetrical ureas 2 in quantitative yields and high purity. (C) 2013 Elsevier Ltd. All rights reserved.

Journal Title

Tetrahedron Letters

Volume

54

Issue/Number

40

Publication Date

1-1-2013

Document Type

Article

DOI Link

http://dx.doi.org/10.1016/j.tetlet.2013.07.141

Language

English

First Page

5467

Last Page

5469

WOS Identifier

WOS:000324452100012

ISSN

0040-4039

Recommended Citation

"Non-phosgene route to unsymmetrical ureas from N-Cbz-alpha-amino acid amides" (2013). Faculty Bibliography 2010s. 4919.
https://stars.library.ucf.edu/facultybib2010/4919