Title
A moment-based approach for DVH-guided radiotherapy treatment plan optimization
Abbreviated Journal Title
Phys. Med. Biol.
Keywords
DOSE-VOLUME CONSTRAINTS; RADIATION-THERAPY; FIELD SEGMENTS; BEAM; WEIGHTS; ALGORITHM; RESTRICTIONS; FRAMEWORK; Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
Abstract
The dose-volume histogram (DVH) is a clinically relevant criterion to evaluate the quality of a treatment plan. It is hence desirable to incorporate DVH constraints into treatment plan optimization for intensity modulated radiation therapy. Yet, the direct inclusion of the DVH constraints into a treatment plan optimization model typically leads to great computational difficulties due to the non-convex nature of these constraints. To overcome this critical limitation, we propose a new convex-moment-based optimization approach. Our main idea is to replace the non-convex DVH constraints by a set of convex moment constraints. In turn, the proposed approach is able to generate a Pareto-optimal plan whose DVHs are close to, or if possible even outperform, the desired DVHs. In particular, our experiment on a prostate cancer patient case demonstrates the effectiveness of this approach by employing two and three moment formulations to approximate the desired DVHs.
Journal Title
Physics in Medicine and Biology
Volume
58
Issue/Number
6
Publication Date
1-1-2013
Document Type
Article
Language
English
First Page
1869
Last Page
1887
WOS Identifier
ISSN
0031-9155
Recommended Citation
"A moment-based approach for DVH-guided radiotherapy treatment plan optimization" (2013). Faculty Bibliography 2010s. 4921.
https://stars.library.ucf.edu/facultybib2010/4921
Comments
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