A moment-based approach for DVH-guided radiotherapy treatment plan optimization
Abbreviated Journal Title
Phys. Med. Biol.
DOSE-VOLUME CONSTRAINTS; RADIATION-THERAPY; FIELD SEGMENTS; BEAM; WEIGHTS; ALGORITHM; RESTRICTIONS; FRAMEWORK; Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging
The dose-volume histogram (DVH) is a clinically relevant criterion to evaluate the quality of a treatment plan. It is hence desirable to incorporate DVH constraints into treatment plan optimization for intensity modulated radiation therapy. Yet, the direct inclusion of the DVH constraints into a treatment plan optimization model typically leads to great computational difficulties due to the non-convex nature of these constraints. To overcome this critical limitation, we propose a new convex-moment-based optimization approach. Our main idea is to replace the non-convex DVH constraints by a set of convex moment constraints. In turn, the proposed approach is able to generate a Pareto-optimal plan whose DVHs are close to, or if possible even outperform, the desired DVHs. In particular, our experiment on a prostate cancer patient case demonstrates the effectiveness of this approach by employing two and three moment formulations to approximate the desired DVHs.
Physics in Medicine and Biology
"A moment-based approach for DVH-guided radiotherapy treatment plan optimization" (2013). Faculty Bibliography 2010s. 4921.