Authors

Z. J. Dai; Y. Peng; B. M. Henry; H. A. Mansy; R. H. Sandler;T. J. Royston

Comments

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Abbreviated Journal Title

J. Acoust. Soc. Am.

Keywords

MAGNETIC-RESONANCE ELASTOGRAPHY; MR ELASTOGRAPHY; MECHANICAL-PROPERTIES; ACOUSTIC TRANSMISSION; RESPIRATORY SYSTEM; SHEAR STIFFNESS; INPUT; IMPEDANCE; CHEST; VISCOELASTICITY; PARENCHYMA; Acoustics; Audiology & Speech-Language Pathology

Abstract

A comprehensive computational simulation model of sound transmission through the porcine lung is introduced and experimentally evaluated. This "subject-specific" model utilizes parenchymal and major airway geometry derived from x-ray CT images. The lung parenchyma is modeled as a poroviscoelastic material using Biot theory. A finite element (FE) mesh of the lung that includes airway detail is created and used in COMSOL FE software to simulate the vibroacoustic response of the lung to sound input at the trachea. The FE simulation model is validated by comparing simulation results to experimental measurements using scanning laser Doppler vibrometry on the surface of an excised, preserved lung. The FE model can also be used to calculate and visualize vibroacoustic pressure and motion inside the lung and its airways caused by the acoustic input. The effect of diffuse lung fibrosis and of a local tumor on the lung acoustic response is simulated and visualized using the FE model. In the future, this type of visualization can be compared and matched with experimentally obtained elastographic images to better quantify regional lung material properties to noninvasively diagnose and stage disease and response to treatment.

Journal Title

Journal of the Acoustical Society of America

Volume

136

Issue/Number

3

Publication Date

1-1-2014

Document Type

Article

Language

English

First Page

1419

Last Page

1429

WOS Identifier

WOS:000342205700053

ISSN

0001-4966

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