Title

Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching

Authors

Authors

C. Kaittanis; T. M. Shaffer; A. Ogirala; S. Santra; J. M. Perez; G. Chiosis; Y. M. Li; L. Josephson;J. Grimm

Comments

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Abbreviated Journal Title

Nat. Commun.

Keywords

DRUG-DELIVERY; MAGNETIC-RELAXATION; CANCER-THERAPY; PROSTATE-CANCER; NANOPARTICLES; NANOSENSORS; TELOMERASE; INHIBITOR; EFFICACY; TUMORS; Multidisciplinary Sciences

Abstract

The effective delivery of therapeutics to disease sites significantly contributes to drug efficacy, toxicity and clearance. Here we demonstrate that clinically approved iron oxide nanoparticles (Ferumoxytol) can be utilized to carry one or multiple drugs. These so called 'nanophores' retain their cargo within their polymeric coating through weak electrostatic interactions and release it in slightly acidic conditions (pH 6.8 and below). The loading of drugs increases the nanophores' transverse T2 and longitudinal T1 nuclear magnetic resonance (NMR) proton relaxation times, which is proportional to amount of carried cargo. Chemotherapy with translational nanophores is more effective than the free drug in vitro and in vivo, without subjecting the drugs or the carrier nanoparticle to any chemical modification. Evaluation of cargo incorporation and payload levels in vitro and in vivo can be assessed via benchtop magnetic relaxometers, common NMR instruments or magnetic resonance imaging scanners.

Journal Title

Nature Communications

Volume

5

Publication Date

1-1-2014

Document Type

Article

Language

English

First Page

11

WOS Identifier

WOS:000334297600001

ISSN

2041-1723

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