Title

Melatonin-Induced Temporal Up-Regulation of Gene Expression Related to Ubiquitin/Proteasome System (UPS) in the Human Malaria Parasite Plasmodium falciparum

Authors

Authors

F. C. Koyama; M. F. Azevedo; A. Budu; D. Chakrabarti;C. R. S. Garcia

Comments

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Abbreviated Journal Title

Int. J. Mol. Sci.

Keywords

melatonin; ubiquitin-proteasome-system; Plasmodium falciparum; malaria; UBIQUITIN-PROTEASOME PATHWAY; CELL-CYCLE; TRYPANOSOMA-CRUZI; PROTEINS; IDENTIFICATION; MODULATION; CHABAUDI; CULTURE; BLOCKS; Biochemistry & Molecular Biology; Chemistry, Multidisciplinary

Abstract

There is an increasing understanding that melatonin and the ubiquitin/ proteasome system (UPS) interact to regulate multiple cellular functions. Post-translational modifications such as ubiquitination are important modulators of signaling processes, cell cycle and many other cellular functions. Previously, we reported a melatonin-induced upregulation of gene expression related to ubiquitin/proteasome system (UPS) in Plasmodium falciparum, the human malaria parasite, and that P. falciparum protein kinase 7 influences this process. This implies a role of melatonin, an indolamine, in modulating intraerythrocytic development of the parasite. In this report we demonstrate by qPCR analysis, that melatonin induces gene upregulation in nine out of fourteen genes of the UPS, consisting of the same set of genes previously reported, between 4 to 5 h after melatonin treatment. We demonstrate that melatonin causes a temporally controlled gene expression of UPS members.

Journal Title

International Journal of Molecular Sciences

Volume

15

Issue/Number

12

Publication Date

1-1-2014

Document Type

Article

Language

English

First Page

22320

Last Page

22330

WOS Identifier

WOS:000346797400045

ISSN

1422-0067

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