Title

Hyperleptinemia is Associated With CRP but Not Apolipoprotein E and is Reduced by Exercise Training

Authors

Authors

J. Lowndes; R. F. Zoeller; G. A. Kyriazis; M. P. Miles; R. L. Seip; N. M. Moyna; P. S. Visich; L. S. Pescatello; P. M. Gordon; P. D. Thompson;T. J. Angelopoulos

Comments

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Abbreviated Journal Title

Int. J. Sport Nutr. Exerc. Metab.

Keywords

exercise physiology; metabolism; gender; endurance training; C-REACTIVE PROTEIN; INDUCED LEPTIN RESISTANCE; PREDICTING BODY DENSITY; E POLYMORPHISM; GENERALIZED EQUATIONS; OBESE HUMANS; WEIGHT-LOSS; E; GENOTYPE; MEN; ATHEROSCLEROSIS; Nutrition & Dietetics; Sport Sciences

Abstract

The purpose of this study was to examine whether leptin levels affect the response of leptin to exercise training (ET) and whether this is also affected by C-reactive protein (CRP) or the three common Apolipoprotein E genotypes (APOE). Ninety-seven (male = 45, female = 52) sedentary individuals underwent 6 months of supervised ET. Blood was sampled before the initiation of ET, and again 24 and 72 hr after completion of the final training session. ET resulted in a small reduction in body mass (80.47 +/- 18.03 vs 79.42 +/- 17.34 kg, p < .01). Leptin was reduced 24 hr after the final exercise session (p < .01), but returned to normal after 72 hr (p > .05)-Pre: 13.51 +/- 12.27, 24hr: 12.14 +/- 12.34, 72hr: 12.98 +/- 11.40 ng/ml. The most hyperleptinemic individuals had a greater initial response, which was sustained through to 72 hr after the final session in the pooled study population (p < .01), and in both males (p < .05) and females (p < .05) separately. CRP was related to leptin independently of body weight and positively related to the reductions in leptin. APOE genotype was not related to leptin levels and did not affect the response to ET. Leptin levels may only be reduced by ET in those with hyperleptinemia. In addition, both the initial extent of hyperleptinemia and the subsequent reduction in leptin may be related to low grade chronic systemic inflammation.

Journal Title

International Journal of Sport Nutrition and Exercise Metabolism

Volume

24

Issue/Number

5

Publication Date

1-1-2014

Document Type

Article

Language

English

First Page

524

Last Page

531

WOS Identifier

WOS:000343640800005

ISSN

1526-484X

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