Title
Combination of Conventional Chemotherapeutics with Redox-Active Cerium Oxide Nanoparticles-A Novel Aspect in Cancer Therapy
Abbreviated Journal Title
Mol. Cancer Ther.
Keywords
OXIDATIVE STRESS; MALIGNANT-MELANOMA; DRUG-DELIVERY; TUMOR-CELLS; DNA-DAMAGE; IN-VITRO; DOXORUBICIN; NANOCERIA; RADIATION; TOXICITY; Oncology
Abstract
Nanotechnology is becoming an important field of biomedical and clinical research and the application of nanoparticles in disease may offer promising advances in treatment of many diseases, especially cancer. Malignant melanoma is one of the most aggressive forms of cancer and its incidence is rapidly increasing. Redox-active cerium oxide nanoparticles (CNP) are known to exhibit significant antitumor activity in cells derived from human skin tumors in vitro and in vivo, whereas CNP is nontoxic and beyond that even protective (antioxidative) in normal, healthy cells of the skin. As the application of conventional chemotherapeutics is associated with harmful side effects on healthy cells and tissues, the clinical use is restricted. In this study, we addressed the question of whether CNP supplement a classical chemotherapy, thereby enhancing its efficiency without additional damage to normal cells. The anthracycline doxorubicin, one of the most effective cancer drugs, was chosen as reference for a classical chemotherapeutic agent in this study. Herein, we show that CNP enhance the antitumor activity of doxorubicin in human melanoma cells. Synergistic effects on cytotoxicity, reactive oxygen species generation, and oxidative damage in tumor cells were observed after co-incubation. In contrast to doxorubicin, CNP do not cause DNA damage and even protect human dermal fibroblasts from doxorubicin-induced cytotoxicity. A combination of classical chemotherapeutics with nongenotoxic but antitumor active CNP may provide a new strategy against cancer by improving therapeutic outcome and benefit for patients. (C) 2014 AACR.
Journal Title
Molecular Cancer Therapeutics
Volume
13
Issue/Number
7
Publication Date
1-1-2014
Document Type
Article
Language
English
First Page
1740
Last Page
1749
WOS Identifier
ISSN
1535-7163
Recommended Citation
"Combination of Conventional Chemotherapeutics with Redox-Active Cerium Oxide Nanoparticles-A Novel Aspect in Cancer Therapy" (2014). Faculty Bibliography 2010s. 6029.
https://stars.library.ucf.edu/facultybib2010/6029
Comments
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