Abbreviated Journal Title
Nat. Commun.
Keywords
TRANSCRIPTION FACTOR; MULTIPLE-SCLEROSIS; BRAIN-INJURY; AGED MICE; IN-VIVO; MICRORNA-9; EXPRESSION; MACROPHAGES; DIFFERENTIATION; PROLIFERATION; Multidisciplinary Sciences
Abstract
Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-kappa B pathway, but not the beta-catenin pathway.
Journal Title
Nature Communications
Volume
5
Publication Date
1-1-2015
Document Type
Article
DOI Link
Language
English
First Page
12
WOS Identifier
ISSN
2041-1723
Recommended Citation
Yao, Honghong; Ma, Rong; Hu, Guoku; Chen, Xufeng; Duan, Ming; Kook, Yeonhee; Niu, Fang; Liao, Ke; Fu, Minggui; Hu, Gang; Kolattukudy, Pappachan; and Buch, Shilpa, "MiR-9 promotes microglial activation by targeting MCPIP1" (2015). Faculty Bibliography 2010s. 6330.
https://stars.library.ucf.edu/facultybib2010/6330
Comments
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