MiR-9 promotes microglial activation by targeting MCPIP1
Abbreviated Journal Title
TRANSCRIPTION FACTOR; MULTIPLE-SCLEROSIS; BRAIN-INJURY; AGED MICE; IN-VIVO; MICRORNA-9; EXPRESSION; MACROPHAGES; DIFFERENTIATION; PROLIFERATION; Multidisciplinary Sciences
Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-kappa B pathway, but not the beta-catenin pathway.
"MiR-9 promotes microglial activation by targeting MCPIP1" (2015). Faculty Bibliography 2010s. 6330.