Deoxyribonucleoside-Modified Squaraines as Near-IR Viscosity Sensors
Abbreviated Journal Title
aggregation; deoxyribonucleosides; near-IR imaging; squaraine dyes; viscosity sensors; LANGMUIR-BLODGETT-FILMS; LIVE CELLS; VISCOELASTIC PROPERTIES; 2-PHOTON; ABSORPTION; CELLULAR-VISCOSITY; SERUM-ALBUMIN; AGGREGATION; DYE; DNA; MICROTUBULES; Chemistry, Multidisciplinary
Deoxyribonucleoside-modified squaraines were synthesized by Sonogashira coupling reactions using an unsymmetrical, terminal alkynylated benzothiazolium squaraine dye. These non-natural nucleosides exhibited fluorescent 'turn-on' properties in viscous conditions with an enhancement of > 300-fold. The viscosity-dependent fluorescence enhancement was attributed to a combination of hampering both molecular aggregation and intramolecular bond rotation of the squaraine probe. Fluorescence microscopy allowed visualization of highly viscous regions during various stages of cellular mitosis.
Chemistry-a European Journal
"Deoxyribonucleoside-Modified Squaraines as Near-IR Viscosity Sensors" (2014). Faculty Bibliography 2010s. 6363.