Title

Resolution of Crohn's disease and complex regional pain syndrome following treatment of paratuberculosis

Authors

Authors

J. T. Kuenstner; W. Chamberlin; S. A. Naser; M. T. Collins; C. T. Dow; J. M. Aitken; S. Weg; G. Telega; K. John; D. Haas; T. M. Eckstein; M. Kali; C. Welch;T. Petrie

Comments

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Abbreviated Journal Title

World J. Gastroenterol.

Keywords

Crohn's disease; Complex regional pain syndrome; Lymphangiomatosis; Mycobacterium avium paratuberculosis; Cure; AVIUM SUBSPECIES PARATUBERCULOSIS; INFLAMMATORY-BOWEL-DISEASE; TYPE-1; DIABETES-MELLITUS; ANTIGEN-PRESENTING CELLS; MYCOBACTERIUM-AVIUM; VITAMIN-D; JOHNES-DISEASE; PULMONARY TUBERCULOSIS; ULTRAVIOLET-LIGHT; ANTIMYCOBACTERIAL THERAPY; Gastroenterology & Hepatology

Abstract

A cohort of family members with various chronic diseases including Crohn's disease, asthma, complex regional pain syndrome, hypothyroidism, type 1 diabetes mellitus, and lymphangiomatosis and/or evidence of infection by Mycobacterium avium subsp. paratuberculosis (MAP) are described in this series of case reports. MAP was cultured from the blood of three members affected by the first five diseases and there was accompanying elevated anti-MAP IgG in two members. The patient affected by the sixth disease has a markedly elevated anti-MAP titer. The two patients affected by the first four diseases have been treated with a combination of anti-MAP antibiotics and ultraviolet blood irradiation therapy with resolution of the disease symptomatology and inability to culture MAP in post treatment blood samples. These case reports of patients with MAP infections provide supportive evidence of a pathogenic role of MAP in humans.

Journal Title

World Journal of Gastroenterology

Volume

21

Issue/Number

13

Publication Date

1-1-2015

Document Type

Article

Language

English

First Page

4048

Last Page

4062

WOS Identifier

WOS:000352852700033

ISSN

1007-9327

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