Title

Drugs in Phase II clinical trials for the treatment of age-related macular degeneration

Authors

Authors

M. J. Tolentino; A. Dennrick; E. John;M. S. Tolentino

Comments

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Abbreviated Journal Title

Expert Opin. Investig. Drugs

Keywords

aflibrecept; age related macular degeneration; bevacizumab; complement; fovista; gene therapy; geographic atrophy; ranibizumab; VEGF; ENDOTHELIAL GROWTH-FACTOR; COMPLEMENT FACTOR-H; INDUCED CHOROIDAL; NEOVASCULARIZATION; PIGMENT EPITHELIAL-CELLS; RETINOL-BINDING-PROTEIN; ANTI-ANGIOGENIC AGENTS; ALTERNATIVE PATHWAY; OCULAR NEOVASCULARIZATION; VITREOMACULAR ADHESION; MONOCLONAL-ANTIBODIES; Pharmacology & Pharmacy

Abstract

Introduction: The clinical development of anti-VEGF therapies for the treatment of exudative age-related macular degeneration (wet AMD) has revolutionized ophthalmology. Indeed, it has provided clinicians and patients with treatments that lessen visual loss from in a disease that once was uniformly blinding. Although blindness is yet to be eradicated from AMD, repeated intraocular anti-VEGF injections are required to preserve a patient's vision. Therefore, further advances in this field are necessary. Areas covered: This review provides an overview of the agents that are in mid-stage phase trials for both exudative (wet AMD) and nonexudative macular degeneration (dry AMD). For wet AMD, new agents intend to enhance efficacy, develop alternative delivery such as eye drops, investigate alternate targets and construct sustained release strategies. For advanced dry AMD, the goal is to develop a strategy to slow or stop progressive loss of retinal tissue seen in geographic atrophy, the hallmark of advanced dry AMD. Expert opinion: It is important to develop better more sensitive biomarkers, validating different approvable clinical trial endpoints and stratifying patients on their genetic polymorphisms. These developments should help to progress the already rapidly developing field of macular degeneration therapy.

Journal Title

Expert Opinion on Investigational Drugs

Volume

24

Issue/Number

2

Publication Date

1-1-2015

Document Type

Review

DOI Link

http://dx.doi.org/10.1517/13543784.2015.961601

Language

English

First Page

183

Last Page

199

WOS Identifier

WOS:000347808500005

ISSN

1354-3784

Recommended Citation

"Drugs in Phase II clinical trials for the treatment of age-related macular degeneration" (2015). Faculty Bibliography 2010s. 6832.
https://stars.library.ucf.edu/facultybib2010/6832